Chemistry Seminar: Mass Spectrometry Instrumentation
Tuesday, October 24, 2017
1:00 PM-2:00 PM
Donald Hunt, PhD,
Departments of Chemistry and Pathology, University of Virginia
Title:
Mass Spectrometry Instrumentation & Methods For The Identification and Sequence Analysis of: (1) Intact Proteins and Large Fragments On A Chromotographic Time-Scale, and (2) Tumor Specific Post-Translationally Modified MHC Peptides For Immunotherapy of Cancer
Abstract:
This lecture will focus on data generated with an ion source that facilitates simultaneous generation of positively charged sample ions by electrospray ionization and negatively charged reagent ions for both electron transfer dissociation (ETD) and ion-ion proton transfer (IIPT) reactions on Orbitrap mass spectrometers. Use of IIPT/ETD facilitates near complete sequence coverage on many intact proteins and is ideally suited for locating multiple posttranslational modifications on the same protein molecule. Also discussed is the identification of post-translationally modified, Class I MHC peptides that trigger central memory T-cells to kill cancer cells. Many of these peptides are found on multiple types of cancer and, thus, are likely candidates for immunotherapy of cancer.
About the Speaker:
Professor Donald F. Hunt joined the faculty at the University of Virginia as an assistant professor in September, 1968 and currently holds the rank of university professor with appointments in both Chemistry and Pathology. He is the recipient of numerous awards including Virginia's Outstanding Scientist, the Pehr Edman Award, the Distinguished Contribution Award from the American Society for Mass Spectrometry, the Christian B. Anfinsen Award from the Protein Society, the ChemicalInstrumentation Award and the Frank F. Field and Joe L. Franklin Award from the American Chemical Society, the Thomson Medal from the International Mass Spectrometry Society, Distinguished Accomplishment Awards from the Human Proteome Organization (HUPO) and ABRF, the Distinguished Scientist Award at the University of Virginia, and the School of Medicine Dean’s Award for Excellence in Team Science.
He is a member of the School of Medicine’s MilliPub Club (5 papers with more than 1,000 citations) and was elected as a member of the American Academy of Arts and Sciences in 2014. He won the American Chemical Society Award in Analytical Chemistry for 2017. Professor Hunt is a co-inventor on more than 30 patents and patent applications and has more than 400 scholarly publications to his credit. His Google scholar h-index of 113, (113 papers with 113 or more citations), i10 index = 357 and 46,448 citations ranks him among the top 130 living chemists in the world. Professor Hunt is a consultant to Thermo Fisher Scientific Corp. and AgenusBio.com
Contact Information
Haifeng (Frank) Ji
215.895.2562
hj56@drexel.edu