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Ryan Petrie Publishes Review Article

April 29, 2016

Ryan Petrie review paper - Origins of Placticity
The decision by a cell to select a particular mechanism of cell migration may simply require a combination of two variables, the degree of cellular contractility and the strength of adhesion to the surrounding matrix.

Ryan Petrie, PhD, assistant professor of biology, published a review article in PubMed titled "Multiple mechanisms of 3D migration: the origins of plasticity". Research over the past few years has revealed that human cells move through three-dimensional tissue, like that found in our bodies, using a surprising variety of unique molecular mechanisms. Remarkably, a single cell is able to switch between multiple distinct mechanisms of migration depending on the physical structure of the material surrounding it. This review summarizes these mechanisms driving 3D cell motility and proposes how they are functionally related to each other.

Read the article: "Multiple Mechanisms of 3D Migration: The Origins of Plasticity"