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Nanoparticle-Based Systems for Imaging of Immune Cell Activation in CNS Disorders

Friday, October 18, 2013

4:00 PM-5:30 PM

Sara Eyal, PhD, senior lecturer at the Institute of Drug Research in The School of Pharmacy and Faculty of Medicine at The Hebrew University, Jerusalem, will discuss how a variety of neurological disorders, including multiple sclerosis, Alzheimer’s disease, epilepsy, glioma, and cerebral malaria, are characterized by the presence of activated phagocytic cells within the central nervous system (CNS). This phenomenon can be exploited for imaging that will be used in clinical and in experimental models of CNS disorders, for detection, localization, and mechanistic studies of disease, and for monitoring of therapy. Dr. Eyal's and her team's goal is the development of biocompatible, nanoparticle-based targeting systems aimed to be administered systemically and detectable by both magnetic resonance and optical imaging, as biomarkers for activated immune cells in the CNS. The talk will present Dr. Eyal's and her team's findings in two animal models of CNS disorders that involve immune cell activation: mice infected with Plasmodium berghi ANKA, as a model of cerebral malaria, and the rat lithium-pilocarpine model of temporal lobe epilepsy. Part of this work has been conducted in collaboration with Dr. Boris Polyak from Drexel's College of Medicine (CoM). For more info, please visit

Contact Information

Banu Onaral

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Bossone Research Enterprise Center, Mitchell Auditorium (Bossone is located at the corner of 32nd and Market Streets).


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