Elizabeth Papish, Ph.D.

Assistant Professor

Office: Stratton Hall 410
Phone: (215) 895-2666
Email: elizabeth.papish@drexel.edu

Fax: (215) 895-1890

Website: http://www.pages.drexel.edu/~ep322/

Research Interests

Our goal is to mimic the structure and function of important metalloenzymes. New ligands are designed to mimic the secondary coordination sphere and provide water-solubility, properties that should lead to fast catalysis of important hydrolysis reactions. The scope of potential research applications is large and includes modeling various esterases, carbonic anhydrase and oxygenases. Model complexes could provide catalysts for green chemistry applications.

Publications

• Kumar, M.; Papish, E. T.; Zeller, M.; Hunter, A. D. “Formation of Biomimetic Structures through the Reaction of Ttz^R,MeZnR′ with Protic Reagents” Dalton Trans. 2010, to be submitted March 2010.
• Bongiovanni, J. L.;* Rowe, B. W.;* Fadden, P. T.;* Taylor, M. T.;* Wells, K. R.;* Kumar, M.; Papish, E. T.; Yap, G. P. A.; Zeller, M. “Synthesis, Structural Studies and Solubility Properties of Zinc(II), Nickel(II) and Copper(II) Complexes of Bulky Tris(triazolyl)borate Ligands” Inorganica Chimica Acta 2010, in press. 
• Kumar, M.; Papish, E. T.; Zeller, M.; Hunter, A. D. “New alkylzinc complexes with bulky tris(triazolyl)borate ligands: Surprising water stability and reactivity” Dalton Trans. 2010, 39, 59-61.
• Gardner, S. R.;* Papish, E. T.; Monillas, W. H.; Yap, G. P. A. “Tris(triazolyl)borate Ligands of Intermediate Steric Bulk for the Synthesis of  Biomimetic Structures with Hydrogen Bonding and Solubility in Hydrophilic Solvents” Journal of Inorganic Biochemistry, 2008, 102, 2179-2183.  In Young Investigator Special Issue: "Inorganic Biochemistry: The Next Generation."
• Papish, E. T.; Donahue, T. M.;* Wells, K. R.;* Yap, G. P. A. “How Are Tris(triazolyl)borate Ligands Electronically Different From Tris(pyrazolyl)borate Ligands? A Study of (Ttz^tBu,Me)CuCO [Ttz^tBu,Me = tris(3-t-butyl-5-methyl-1,2,4-triazolyl)borate].” J. Chem. Soc. Dalton Trans., 2008, 2923-2925.
• Jernigan, F. E.;* Sieracki, N. A.;* Taylor, M. T.;* Jenkins, A. S.;* Engel, S. E.; Rowe, B. W.;* Jové, F. A.; Yap, G. P. A.; Papish, E. T.; Ferrence, G. M. “Sterically Bulky Tris(triazolyl)borate Ligands as Water-Soluble Analogues of Tris(pyrazolyl)borate” Inorg. Chem.  2007, 46, 360-362.
• Jernigan, F. E.;* Jové, F. A.; Papish, E. T.; Yap, G. P. A. "Bis[tris(3-isopropylpyrazolyl)methane sulfonate]manganese(II)" Acta Cryst. E62, 2006, m3172-m3173.
• Papish, Elizabeth T.; Taylor, Michael T.;* Jernigan, Finith E.;* Rodig, Michael J.;* Shawhan, Robert R.;* Yap, Glenn P. A.; Jové, Fernando A. "Synthesis of Zinc, Copper, Nickel, Cobalt and Iron Complexes Using Tris(pyrazolyl)methane Sulfonate Ligands:  A Structural Model for N,N,O Binding in Metalloenzymes" Inorganic Chemistry 2006, 45, 2242-2250.
• Mahajan, Devinder; Papish, Elizabeth T.; Pandya, Kaumudi.  “Sonolysis Induced Decomposition of Metal Carbonyls: Kinetics and Product Characterization.” Ultrasonics Sonochemistry 2004, 11, 385-392.
• Tang, LiHao; Papish, Elizabeth T.; Abramo, Graham P.; Baik, Mu-Hyun; Norton, Jack R.; Rappé, Anthony. “Kinetics and Thermodynamics of H• Transfer From (h⁵-C₅R₅)Cr(CO)₃H to Styrene and Methyl Methacrylate”.  J. Am. Chem. Soc. 2003, 125, 10093-10102.
• Papish, Elizabeth T.; Magee, Matthew P.; Norton, Jack R.  “Protonation of Transition Metal Hydrides to Give Dihydrogen Complexes: Mechanistic Implications and Catalytic Applications”.  In Recent Advances in Hydride Chemistry; Poli, R., Ed.; Elsevier: Switzerland, 2001; pp 39-74.
• Papish, Elizabeth T.; Rix, Francis C.; Spetseris, Nikos; Norton, Jack R.; Williams, Robert D. “Protonation of CpW(CO)₂(PMe₃)H: Is the Metal or the Hydride the Kinetic Site?” J. Am. Chem. Soc.  2000, 122, 12235-12242.
• Wu, Min; Papish, Elizabeth T.; Begley, Tadhg P. “Mechanistic studies on thiaminase I. Identification of the product of thiamin degradation in the absence of the nucleophilic cosubstrate.” Bioorg. Chem. 2000,  28,  45-48.