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Uri Hershberg

Uri Hershberg, PhD

Associate Professor
School of Biomedical Engineering, Science & Health Systems

Office: Monell 102
Phone: 215.895.1698
Website: Systems Immunology Lab


  • PhD Computational Biology, Thesis: The Emergence of Meaning in Biological Systems. Interdisciplinary Center for Neural Computation (ICNC), Hebrew University of Jerusalem, Israel. 2005
  • MS Neural Computation, Hebrew University. 1999 
  • BS Double major in Biology and Psychology. Cum laude. Hebrew University of Jerusalem, Israel. 1996

Research Interests

Bioinformatics, immunology, neural computation, system biology, somatic selection, autoimmunity, genetic stability, germline diversity, dendritic cell, transcription elements, pathogens, computational and mathematical modeling, complex systems, cognition and inflammation


Uri Hershberg, PhD, is an Associate Professor at the Drexel University School of Biomedical Engineering, Science and Health Systems and in the Department of Immunology and Microbiology at the Drexel University College of Medicine. He has a wide background in biology and computational methods. He was previously a Post Doc with Professor Mark Shlomchik, and then Associate Research Scientist with Professor Steven Kleinstein at the Yale School of Medicine. At Yale, Dr. Hershberg used computational tools to study the anti-viral response in dendritic cells and the dynamics of the B-cell repertoire in healthy and pathological immune responses. He was educated at the Hebrew University, where he received a PhD in Computational Biology at the Interdisciplinary Center for Neuronal Computation under the supervision of Professor Irun Cohen of the Department of Immunology at the Weizmann Institute and Professor Sorin Solomon of the Rakah Theoretical Physics Institute at the Hebrew University. His PhD titled "The Emergence of Meaning in Biological Systems" dealt with the ability of the T-cell repertoire in the immune system to defend from pathogens and maintain its diversity without attacking the body. Dr. Hershberg has published over 30 papers on topics related to B-cell, T-cell, and dendritic cell immunity, as well as the defining complex system criteria of cognitive perceptual systems, using the immune system as an example. He is on the editorial board of several publications and on the organizing committee of the International Conference on Artificial Immune Systems.