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Jeffery Twiss, Ph.D., M.D.

Department Head, Professor

Jeffery L. Twiss, M.D., Ph.D.

Office: PISB 123.04
Phone: (215) 895-2624
Email: jlt98@drexel.edu
Lab: PISB 413
Lab Phone: (215) 895-3785

Specialization:

Molecular and cellular neurobiology


Education

  • B.S., College of Charleston, 1984
  • M.D., Medical Unversity of South Carolina, Charleston, SC, 1990
  • Ph.D., Medical University of South Carolina, Charleston, SC (Molecular & Cellular Biology), 1992
  • Residency, Stanford University Medical Center, Stanford, CA (Anatomic Pathology & Neuropathology), 1990-1992
  • Post-doctoral fellowship, Stanford University, Stanford, CA (Molecular Neurobiology), 1992-1996

Research Interests

Nerve growth, regeneration, and neuroprotection focusing on gene expression and signal transduction mechanisms.

Publications

  • D.E. Willis, E. van Niekerk, Y. Sasaki, M. Mesgnon, T.T. Merianda, G.G. Williams, M. Kendall, D.S. Smith, G.J. Bassell, and J.L. Twiss. (2007). Extracellular stimuli specifically regulate localization of individual neuronal mRNAs. J. Cell Biol. 178: >
  • E. van Niekerk, J.H. Chang, D.E. Willis, K. Reumann, T. Heise, and J.L. Twiss. (2007). Sumoylation in axons triggers retrograde transport of the RNA binding protein La. Manuscript submitted to Proc. Natl. Acad. Sci., USA 104:12913-12918.
  • T.T. Merianda, A. Lin, J. Lam, D. Vuppalanchi, D.E. Willis, N. Karin, C.E. Holt, and J.L. Twiss. (2009). A functional equivalent of endoplasmic reticulum and golgi in axons for secretion of locally synthesized proteins. Mol Cell Neurosci 40:128-42.
  • M.A. Rivieccio, C. Brochier, D.E. Willis, B.A. Walker, M.A. D’Annibale, K. McLaughlin, A. Siddiq, A.P. Kozikowski, S.R. Jaffrey, J.L. Twiss , R.R. R 09). HDAC6 is a target for protection and regeneration following injury in the nervous sytem. Proc Natl Acad Sci 106:19599-604.
  • T. Ma, A. Campana, P. Lange, H.-H. Lee, K. Banerjee, J.B. Bryson, L. Mahishi, S. Alam, R. Giger, S. Barnes, S. Morris, D.E. Willis, J.L Twiss, M. Filbin, and R. Ratan. (2010). A large scale chemical screen for regulators of the arginase 1 promoter identifies the soy isoflavone, daidzein as a clinically approved, small molecule that can promote neuronal protection or regeneration via a cAMP-independent pathway. J Neurosci 30:739-48.
  • D. Vuppalanchi, J. Coleman, S. Yoo, T.T. Merianda, A.G. Yadhati, J. Hossain, A. Blesch, D.E. Willis, and J.L. Twiss. (2010). Conserved 3'UTR sequences direct subcellular localization of chaperone pro tein mRN Chem. 285:18025-38.
  • C.J. Donnelly, M. Fainzilber, and J.L. Twiss. (2010). Subcellular communication through RNA transport and localized protein synthesis. Traffic 11:1498-505.
  • Li S, Overman JJ, Katsman D, Kozlov SV, Donnelly CJ, Twiss JL, Giger RJ, Coppola G, Geschwind DH, Carmichael ST. (2010). An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke. Nature Neurosci.13:1496-504.
  • LF Gumy, GSH Yeo, Y-C L Tung, K. Zivraj, DE Willis, G Coppola, BYH Lam, JL Twiss, CE Holt, and JW Fawcett. (2011). Global transcriptome analysis reveals differences between embryonic and a dult dor mRNAs that are implicated in axonal growth and pain. RNA 17:85-98.
  • Barrientos S., Martinez N.W. , Yoo S., Jara J.S., Zamorano S., Hetz C., Twiss J.L., Alvarez J., and Court F. A. (2011). Axonal degeneration is mediated by the mitochondrial permeability transition pore. J. Neurosci 31:966-978.